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Research reveals genetic conversation between X and Y chromosomes

Published on September 10, 2009 at 3:46 AM · No Comments

In the week that the University of Leicester celebrates the 25th anniversary of the discovery of DNA fingerprinting (Thursday September 10) new findings from the world-renowned University of Leicester Department of Genetics reveal for the first time that the male and female do truly communicate -at least at the fundamental genetic level.

The research counters scientific theory that the X and Y chromosomes - that define the sexes - did not communicate at all.

The research is funded by the Wellcome Trust, and published in The American Journal of Human Genetics. In it Dr Zoë Rosser and colleagues have shown that exchange of DNA does actually occur between the X and Y in the regions previously thought to be completely isolated.

Professor Mark Jobling, who led the study, said: "Recently it was shown that the Y chromosome can talk to itself - swapping bits of DNA from one region to another, and potentially giving it a way to fix mutations that might affect male fertility. In this new research we've now shown that it actually maintains a genetic conversation with the X chromosome, potentially giving it a way to fix other kinds of mutations, too. So, maybe it's not quite the dysfunctional loner we have always imagined it to be."

The X and Y chromosomes have a vital role-  sex is determined by them. Apart from the 22 pairs of regular chromosomes all of us share, women have two X chromosomes, while men have only one X but also the smaller Y chromosome. It's the Y that determines maleness by triggering development of testes rather than ovaries in the early embryo.

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