Clinical data on CXA-101 to be presented at ICAAC

Calixa Therapeutics Inc., a clinical-stage biopharmaceutical company focused on the development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, will present pre-clinical and clinical data in 20 posters at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) that is being held in San Francisco on September 12 to 15, 2009. The presentations will include comprehensive in vitro, in vivo, and clinical data on Calixa's anti-pseudomonal cephalosporin, CXA-101, alone and in combination with the beta-lactamase inhibitor, tazobactam.

CXA-101 is a potent, intravenously administered, anti-pseudomonal cephalosporin currently in Phase 2 study for the treatment of complicated urinary tract infections. Calixa recently initiated a Phase 1 study in healthy subjects for a second product, CXA-101/tazobactam. Tazobactam is a well established beta-lactamase inhibitor that could further enhance the excellent antibacterial activity of CXA-101 and potentially increase its clinical utility.

"This is an outstanding achievement for Calixa," said James Ge, M.D., Ph.D., chief scientific officer and executive vice president, of Calixa. "The 20 presentations give us a very strong presence at this major infectious disease conference, and reflect significant progress over the past year. We are particularly enthusiastic about the excellent clinical safety and pharmacokinetics profile CXA-101 exhibited in the Phase 1 studies conducted to date. We look forward to moving this promising compound, alone and in combination with tazobactam, to the next stages of clinical development."