Halozyme Therapeutics, Inc. (Nasdaq: HALO) today announced additional Phase 2 results that demonstrated faster insulin absorption and increased peak insulin concentrations in type 1 diabetic patients after co-administration of its recombinant hyaluronidase enzyme (rHuPH20 or PH20) with Humulin® R (regular human insulin), a mealtime insulin. In addition, study results also showed a significant reduction in postprandial blood glucose levels following administration of a standardized test meal and less hypoglycemia compared to Humulin R alone. These results provide additional confirmation in type 1 diabetes patients of the effects observed in a Phase 1 study conducted in healthy volunteers. The company presented these results today at the European Association for the Study of Diabetes in Vienna.
“This study has demonstrated faster insulin absorption and a shorter blood insulin concentration profile for both combinations of lispro and regular insulin plus PH20 compared to either insulin alone in type 1 diabetic patients. The PK shift results in lower hyperglycemia after a meal,” stated Doug Muchmore, M.D., vice president, endocrinology clinical development. The results from the study for Humalog® (insulin lispro) with and without PH20 were previously presented at the American Diabetes Association meeting in June 2009.