Researchers at five research centers have been awarded an $11 million, two-year grant from the National Heart Lung and Blood Institute as part of the NIH Recovery Act that will allow a team of national scientists to delve deeply into the biology of two fatal lung diseases for which there are few therapeutic options. The multi-center Lung Genomics Research Consortium will use advanced genetic and molecular tools to characterize and better understand chronic obstructive pulmonary disease and pulmonary fibrosis, then share its discoveries with researchers around the world in a web-accessible data warehouse.
"Our aim is create a genetic and molecular treasure trove for the research community to redefine these lung diseases precisely and unequivocally," said David Schwartz, MD, one of the lead researchers on the project and Director of The Center for Genes, Environment and Health at National Jewish Health. "The genetic, epigenetic, transcriptional, and phenotypic data we generate will provide an unprecedented window into the origins, dynamic biological features and unique presentations of these diseases. It will allow researchers to make fundamental discoveries that help identify individuals at risk for these diseases, diagnose them earlier, and develop more effective, personalized treatments."
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. The incidence of pulmonary fibrosis has doubled over the past decade, and now kills about 40,000 Americans each year. There are few effective treatments for either disease, and both diseases are fatal.