According to the great paradigms of immunology, asthma, an allergic disease of the respiratory system, should always develop upon exposure to airborne antigens that are constantly being inhaled. However, the fact that 94 % of the Western population does not develop the disease suggests that as yet undefined mechanisms protect the respiratory tract from developing an allergic response. A team of researchers at University of Liege (Belgium), GIGA Research Center, led by Professor Fabrice Bureau, has shown that asthma is inhibited by regulatory macrophages, a cell population never previously described.
Asthma affects 6 % of the population and kills twenty thousand people in Europe each year. Patients suffering from the disease first develop, often at a very early age, a useless and even harmful immune reaction to airborne allergens (mite excrement, pet scales, pollens, etc.). Whenever exposed to these allergens, the patient's innate respiratory immune system is reactivated, thereby inducing a narrowing of the airways, which in turn results in insufficient oxygenation.
As the airborne antigens we take in with each breath are foreign to our bodies, this should elicit a response of the immune system. Moreover, ambient air contains a significant number of immunostimulatory molecules (bacterial endotoxins) that act as danger signals and should prompt the immune system to respond to the inhaled antigens. If this were so, the entire population would be asthmatic.