Immunization with either live attenuated influenza vaccine (LAIV, also known as FluMist®), or trivalent inactivated influenza vaccine (TIV), appears to offer a protection (~ 45%) against the novel A/H1N1 virus, the cause of the present influenza pandemic. However, the benefit was largely attributed to the youngest age group. The finding emerges from an evaluation of medical encounters and seasonal influenza immunization of U.S. military service members.
As reported today in a Late-Breaker presentation at the 58th annual meeting of the American Society of Tropical Medicine and Hygiene (ASTMH), seasonal influenza vaccination also appears to offer higher protection against severe disease requiring hospitalization (~ 62%, 95% confidence interval [CI], 14% to 84%) than against milder infections that can be treated on an outpatient basis (~ 42%, 95% CI, 29% to 53%).
"The increasing momentum of the H1N1 pandemic underscores the need for vaccination, yet there is a wide variance in vaccine effectiveness depending on the strain-match for a particular season," comments Col. (Ret.) Jose L. Sanchez, MD, MPH, of the Armed Forces Health Surveillance Center (AFHSC) in Silver Spring, Maryland.
Dr. Sanchez and colleagues conducted a case control analysis of influenza-related medical encounter data of U.S. military service members, compared to a control group of personnel with acute, non-respiratory illnesses. For the period of April-October 2009, a total of 1,205 cases of pandemic H1N1 2009 infections were reported, of which 966 (80%) were among males and more than one-half (58%) were among those younger than 25 years. The overall vaccine effectiveness (VE) for service members was found to be 45% (95% confidence interval [CI], 33% to 55%). Immunization with prior season's TIV>
Interestingly, and unexpectedly, the investigators observed a U-shaped relationship of VE with age stratification. VE was high in the youngest (< 25 yo) and oldest (> 39 yo) service members (50% and 55% respectively), while there was noVE for those 25 to 39 years of age.