Aptuit, Inc. today announced the publication of new research in the
December issue of the European Journal of Pharmaceutical Sciences,
the official journal of the European Federation for Pharmaceutical
Sciences (EUFEPS), which describes the solid-state characterization of
three forms of finasteride. The study, conducted by researchers at SSCI,
a Division of Aptuit, outlines a systematic approach to characterizing a
set of solvated active pharmaceutical ingredients (APIs) and evaluating
the solid-state behavior of each. The research uncovered previously
uncharacterized API forms within an existing family of finasteride
solvates, demonstrating that Aptuit’s approach to applying solid-state
chemistry may lead to the early identification of new API forms with
improved pharmaceutical properties.
“Interestingly, in our initial efforts to determine the approximate
solubility for subsequent solid-form screens on finasteride, we noticed
unique recrystallization properties that prompted this study. We then
set forth in generating, characterizing and investigating the
solid-state behavior of three finasteride solvates,” explained Nathan
Schultheiss, PhD, Research Investigator at SSCI, a Division of Aptuit,
and lead investigator of the published study. “Through our work, we
gained unparalleled insight into the crystallographic and
thermoanalytical behavior of the compound.”