Chemists and biologists from the University of Bath have developed a new technique that could be used to diagnose and develop treatments for age-related conditions like Alzheimer's disease, diabetes and cancer.
In these diseases, proteins in the body react with sugars in a process called glycation. This modifies the protein's function and can trigger complications such as inflammation and premature aging.
The team at Bath, led by Dr Jean van den Elsen and Dr Tony James, has developed a technique that can detect glycated proteins and could in the future be used for diagnosing a whole range of diseases in patients.
They used a technique called gel electrophoresis, where samples are put into a thin gel layer and an electric current is applied. The gel acts like a molecular sieve, sorting proteins from the samples according to their size and shape, allowing scientists to identify whether specific proteins are present in the blood.
For this study, the researchers have patented a new type of gel electrophoresis, which uses boronic acid to distinguish between the glycated and unmodified proteins.
Dr Tony James from the University's Department of Chemistry explained: "Not all sugars are 'bad' - in fact many proteins contain beneficial 'good' sugar units.
"However, some sugars can be 'bad' and cause complications in diseases such as Alzheimer's and diabetes.
Dr Jean van den Elsen, from the University's Department of Biology & Biochemistry, said: "Our method specifically recognises these 'bad' sugars in the presence of the 'good' sugars and as such is an excellent diagnostic tool."
PhD student Marta Pereira Morais added: "We believe our method will also aid the development of new drug based therapies for these diseases."