Clinical trial launched to test new treatment technique for bowel cancer
Cancer Research UK this week launches a new trial for patients with bowel cancer that has spread to the liver to see whether a new radiotherapy treatment technique is more effective than standard chemotherapy.
Researchers at trial centres across the UK and coordinated at Oxford University will test a new treatment called Radio-embolisation, a form of internal radiotherapy that uses the tumour's blood supply to target multiple sites of disease within the liver. They will combine this new treatment with standard chemotherapy in patients recently diagnosed with bowel cancer that has spread to the liver.
The first patient will start the treatment this week at the Royal Surrey County Hospital in Guildford.
Despite major advances in treating advanced bowel cancer, the number of patients who survive beyond five years remains disappointingly low - less than 10 per cent.
The trial - called FOXFIRE and funded by Cancer Research UK and by Sirtex Medical Ltd.- aims to recruit almost 500 patients in the UK with advanced bowel cancer. The results are being combined with an international study called SIRFLOX, meaning that over 800 patients will be studied worldwide.
The patients will be divided into two groups at random. One group will receive chemotherapy plus Radio-embolisation and the other will receive chemotherapy alone.
Dr Ricky Sharma, the chief investigator from the Cancer Research UK and Medical Research Council Gray Institute for Radiation Oncology and Biology at the University of Oxford, said: "Although we now have several new ways of treating bowel cancer which has spread to the liver, we are keen to develop other novel techniques to improve treatment.