A new study pinpoints the genetic changes that enable Tibetans to thrive at altitudes where others get sick.
In the online edition of Proceedings of the National Academy of Sciences, an international team has identified a gene that allows Tibetans to live and work more than two miles above sea level without getting altitude sickness.
A previous study published May 13 in Science reported that Tibetans are genetically adapted to high altitude. Now, less than a month later, a second study by scientists from China, England, Ireland, and the United States pinpoints a particular site within the human genome - a genetic variant linked to low hemoglobin in the blood - that helps explain how Tibetans cope with low-oxygen conditions.
The study sheds light on how Tibetans, who have lived at extreme elevation for more than 10,000 years, have evolved to differ from their low-altitude ancestors.
Lower air pressure at altitude means fewer oxygen molecules for every lungful of air. "Altitude affects your thinking, your breathing, and your ability to sleep. But high-altitude natives don't have these problems," said co-author Cynthia Beall of Case Western Reserve University. "They're able to live a healthy life, and they do it completely comfortably," she said.
People who live or travel at high altitude respond to the lack of oxygen by making more hemoglobin, the oxygen-carrying component of human blood. "That's why athletes like to train at altitude. They increase their oxygen-carrying capacity," said Beall.
But too much hemoglobin can be a bad thing. Excessive hemoglobin is the hallmark of chronic mountain sickness, an overreaction to altitude characterized by thick and viscous blood. Tibetans maintain relatively low hemoglobin at high altitude, a trait that makes them less susceptible to the disease than other populations.
"Tibetans can live as high as 13,000 feet without the elevated hemoglobin concentrations we see in other people," said Beall.
To pinpoint the genetic variants underlying Tibetans' relatively low hemoglobin levels, the researchers collected blood samples from nearly 200 Tibetan villagers living in three regions high in the Himalayas. When they compared the Tibetans' DNA with their lowland counterparts in China, their results pointed to the same culprit - a gene on chromosome 2, called EPAS1, involved in red blood cell production and hemoglobin concentration in the blood.
Originally working separately, the authors of the study first put their findings together at a March 2009 meeting at the National Evolutionary Synthesis Center in Durham, NC. "Some of us had been working on the whole of Tibetan DNA. Others were looking at small groups of genes. When we shared our findings we suddenly realized that both sets of studies pointed to the same gene - EPAS1," said Robbins, who co-organized the meeting with Beall.