Synageva BioPharma, to-BBB to evaluate brain drug delivery technology

Synageva BioPharma Corp. and to-BBB technologies BV, the Dutch drug brain delivery company, have entered into a research collaboration to evaluate the potential of transporting therapeutic proteins across the blood-brain barrier into the central nervous system (CNS). The blood-brain barrier, a protective filter for the CNS, can be an obstacle for protein therapeutics and prevent these treatments from reaching their site of action within the CNS. A number of rare diseases that could benefit from protein therapeutics have a CNS component and require the therapies to be transported across the blood-brain barrier. This research collaboration will be the basis for a development program for therapies for multiple such rare diseases, including Lysosomal Storage Diseases (LSDs).

“Synageva is pleased to have entered into this collaboration with to-BBB to evaluate their drug delivery technology”

"Synageva is pleased to have entered into this collaboration with to-BBB to evaluate their drug delivery technology," said Anthony Quinn, Synageva's Chief Medical Officer and Head of R&D. "This collaboration, which combines Synageva's proprietary compounds and technology with to-BBB's expertise in CNS delivery, provides Synageva with an opportunity to extend the therapeutic benefits of our pipeline products targeting rare diseases with CNS manifestations."

"We are very pleased to collaborate with Synageva," said Pieter Gaillard, CSO of to-BBB. "to-BBB's brain delivery technology combined with Synageva's significant rare disease expertise should result in substantial progress towards the development of innovative medicines for untreated CNS diseases."