Large clinical trial to test new device for detecting Barrett's oesophagus

Published on July 25, 2011 at 12:56 AM · No Comments

CANCER RESEARCH UK has launched a large multi-centre trial to test a new device for detecting Barrett's oesophagus - a condition that puts sufferers at increased risk of developing cancer of the oesophagus, one of the most deadly cancers.

In the last thirty years oesophageal cancer rates have risen dramatically in the UK compared with many other Western countries, particularly for a certain type called adenocarcinoma, which is linked to Barrett's oesophagus.

The trial will examine whether a promising new test called 'cytosponge' could provide an improved method of identifying patients with Barrett's oesophagus, so they can be offered treatment to reduce their risk of oesophageal cancer.

The test involves patients swallowing a small capsule with a string attached, which dissolves in the stomach and expands to form a 3cm sponge.

The sponge is gently drawn back out using the string, removing a small sample of the cells lining the oesophagus as it passes, which can be tested in the lab for early signs of cancer.

Each test should cost just £25, compared with £400 for a traditional endoscopy, and the procedure is far less invasive.

Chief Investigator Dr Rebecca Fitzgerald, who led the Cambridge-based team that developed the cytosponge test, said: "If this trial is successful it will provide a cheap, safe and highly effective method of identifying people with Barrett's oesophagus, so they can take steps to reduce their risk of developing cancer.

"This would open the doors for a national screening programme, much like those offered for breast, cervical and bowel cancers, to help prevent oesophageal cancer among the one to two people in every 100 with Barrett's oesophagus who go on to develop the disease."

Oesophageal cancer is the sixth most common cause of death from cancer in the UK, with around 7,500 people dying from the disease each year. It is often diagnosed at a late stage, making it difficult to treat, and this largely accounts for the poor survival rates.

Persistent heartburn or indigestion, caused by stomach acid coming back up the gullet, is a major risk factor for cancer of the oesophagus. Over time this can cause the cells lining the lower oesophagus to start to resemble those found in the small and large intestines, a condition known as Barrett's oesophagus.

But if the condition can be diagnosed before cancer develops, patients can be offered closer monitoring and treatment to help remove abnormal cells.

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