New cold electron source could improve quality and speed of nanoimaging for drug development

A new source of very cold electrons will improve the quality and speed of nanoimaging for drug and materials development to a trillionth of a second.

The study published in Nature Physics today was carried out by researchers from the ARC Centre of Excellence for Coherent X-ray Science (CXS), headquartered at the University of Melbourne.

Associate Professor Robert Scholten from the University's School of Physics and the CXS, said the new cold electron source offered potential advances in electron imaging at the atomic or nanoscale which will have real applications in a range of industries including health.

"Enhanced nanoimaging using this cold source will enable us to design better drugs for more targeted treatments. Having a better visibility of the structure of a cell membrane protein and how it functions will assist in more targeted drug design.

"It will also help us understand how vulnerabilities such as cracks form, when designing new materials for advanced technology such as in turbine blades for jet engines.

"Nano imaging using electron microscopy give us intricate images of the micro and nanoscale world, but conventional hot electron sources are incoherent - like the indirect light of light bulbs versus direct laser beams.

"Depending on the target, it can take several minutes to several hours to undergo this process and the image is not very clear.'

"Our experiments have revealed that with cold electrons and our new technology, we will be able to take a snapshot of the whole sample with atomic resolution and to reduce the imaging time to a trillionth of a second," he said.

The team led by Associate Professor Scholten used lasers to cool atoms to a few millionths of a degree above absolute zero and then to extract a beam of extremely cold electrons.

Using new technology, they were able to create beams in complex shapes, and because the electrons are so very cold (about 10 degrees above absolute zero) the beam retains that shape, rather than exploding as it would for a conventional hot electron source.

"This new cold source will allow us to see dynamic processes within the sample, to understand how it functions on a more precise level," he said.

"Cold electron technology opens up a whole new world of imaging - this study is the first to show its real potential," he said.

It is hoped the technology will be further developed in the next few years.