Breast cancer screening effectiveness under scrutiny yet again

Published on October 26, 2011 at 6:31 PM · 1 Comment

By Dr Ananya Mandal, MD

There has been a lot of debate regarding the effectiveness of breast cancer screening in the UK. It is being reviewed yet again. The NHS says screening saves lives, but other researchers have argued that it may cause more harm than good.

The national cancer director for England, Prof Mike Richards, announced in the British Medical Journal that he will lead a review. He said he was taking the “current controversy very seriously”.

There have been studies that show that screening programmes for a range of cancers help doctors make a diagnosis sooner. But they also run the risk of false positives, diagnosing someone with cancer when they are healthy. Screening was introduced for breast cancer in 1988 in the UK and now offers tests to women, over the age of 50, every three years. In 2002, the World Health Organization's International Agency for Research on Cancer estimated that screening reduced deaths from breast cancer by about 35%. The NHS says 1,400 lives are saved through screening in England alone.

However, the evidence has been questioned. A review of clinical trials involving a total of 600,000 women concluded it was “not clear whether screening does more good than harm”. It said that for every 2,000 women screened in a 10-year period: one life would be saved, 10 healthy women would have unnecessary treatment and at least 200 women would face psychological distress for many months because of false positive results. The authors of that research labeled the NHS Breast Screening Programme's advice “seriously misleading”.

“Should the independent review conclude that the balance of harms outweighs the benefits of breast screening, I will have no hesitation in referring the findings to the UK National Screening Committee and then ministers. You also have my assurance that I am fully committed to the public being given information in a format that they find acceptable and understandable and that enables them to make truly informed choices,” wrote Richards in a letter to the BMJ.

Prof Julietta Patnick, director of the NHS Cancer Screening Programmes, welcomed the review, “The NHS Breast Screening Programme has always been based on the best and latest evidence. Where new information has suggested them, a number of changes have been made to the Programme, for example extending the screening age range and using digital mammography.”

The director of health information at the charity, Sara Hiom, said, “Women need more accurate, evidence-based and clear information to be able to make an informed choice about breast screening. The decision whether to be screened is a personal one, but that decision should be made with all of the potential harms and benefits fully explained.”

Breakthrough Breast Cancer's chief executive Chris Askew said, “Breast screening is vital as it can detect breast cancer at the earliest possible stages when no other symptoms are obvious. The earlier breast cancer is picked up the better for the one in eight women who are diagnosed every year with this disease, as treatment options are more likely to be less aggressive and have successful outcomes.”

In the meantime, the Department of Health insisted, “Our advice has not changed - we urge all women to go for breast screening when invited. The best available evidence shows that screening saves lives by detecting cancers earlier than they would otherwise have been.”

The review will be led jointly by Prof Richards and Cancer Research UK.

Posted in: Women's Health News

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Comments
  1. Elizabeth Elizabeth Australia says:

    The dishonesty and vested interests in these programs is quite frightening and it's all very political. Those urging screening are usually protecting their jobs, influence/power base, profits or chasing votes.

    At least the UK has some amazing advocates for informed consent, we have no high profile advocates protecting women from harm, warning us of risk and keeping these programs honest and ethical. These programs IMO, are harmful and there to serve the interests of others, not women.

    Informed consent is a joke...for women. It's respected in prostate screening.

    I hope some of this filters down here, but with no one saying or doing anything, I fear nothing will change - we'll keep over-screening for cervical cancer and harming as many women as possible and we'll keep risk and controversy hidden in both programs - in favour of reaching political goals and targets.

    Thank heavens for the internet - I don't participate in either program. I examine the facts and assess my risk profile and I always assume anything the screening authorities say is biased and in THEIR best interests and sadly, I'm usually right.

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