Circadian rhythm can influence a heart attack

Published on February 23, 2012 at 5:52 PM · No Comments

By Dr Ananya Mandal, MD

Researchers have found that a biological clock can influence a heart attack. The risk of “sudden cardiac death” peaks in the morning and rises again in the evening as shown in lab animals.

The inner workings of the body go through a daily routine known as a circadian rhythm, which keeps the body in sync with its surroundings. Jet lag is the result of the body getting out of sync. As the chemistry of the body changes throughout the day, this can impact on health. US researchers say they have identified, in mice, how the time can affect the risk of sudden cardiac death, which kills 100,000 people a year in the UK.

A study published in the journal Nature suggests that levels of a protein which controls the heart's rhythm fluctuates through the day. The protein called kruppel-like factor 15 (Klf15), which was controlled by the body clock and whose levels in the body went up and down during the day was detected. Genetically modified mice which produced too much Klf15 and those which produced none at all both had an increased risk of developing deadly disturbances in cardiac rhythm.

“It is the first example of a molecular mechanism for the circadian change in susceptibility to cardiac arrhythmias,” said Xander Wehrens of Baylor College School of Medicine in Houston, Texas. “If there was too much Klf15 or none, the mice were at risk for developing the arrhythmia.”

Prof Darwin Jeyaraj, from the Case Western Reserve University School of Medicine, said, “Our study identifies a hitherto unknown mechanism for electrical instability in the heart. It provides insights into day and night variation in arrhythmia susceptibility that has been known for many years.”

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