UCSF to create first implantable device for patients with kidney failure

Published on October 3, 2012 at 1:54 AM · 1 Comment

A $750,000 gift from the John and Marcia Goldman Foundation is spurring a UCSF-led effort to create the first implantable artificial kidney for patients with kidney failure.

The new funds, which augment a $2.25 million grant for the project from the National Institutes of Health this summer, will enable the team of bioengineers, physicians and scientists to conduct the critical research needed to bring the proposed device to clinical trials by 2017.

"Kidney failure takes a terrible toll on the world, both economically and in human suffering," said Shuvo Roy, PhD, an associate professor in the UCSF School of Pharmacy who is leading The Kidney Project through the UCSF Department of Bioengineering & Therapeutic Sciences. "These funds are a critical step in helping us move this project forward more quickly and ultimately bring real solutions to patients throughout the world."

Working with the project's medical director, William Fissell, MD, at Vanderbilt University, UCSF's Roy is coordinating researchers in nine institutions nationwide to create an implantable device that aims to mimic the filtration functions of a kidney, as well as its ability to maintain water and salt balances, produce Vitamin D, and regulate blood pressure and pH.

He estimates that the project will require an additional $13 million to bring that technology through the range of tests needed to enter clinical trials in humans.

The Goldmans said they contributed to this unique research because of the project's specific goal of addressing the dire shortage of donated kidneys and eliminating the need for dialysis.

"We know how debilitating dialysis is, and how few options are available for people with kidney failure," said Marcia Goldman, who directed the gift with her husband through the John and Marcia Goldman Foundation. "The opportunity to be part of a potential solution of this scale was very appealing to us."

Roughly 2 million people worldwide live with end-stage renal disease (ESRD), commonly known as chronic kidney failure, including 600,000 Americans - a figure that is rising 5 percent per year in lockstep with the growing rate of diabetes. The disease is best treated via a kidney transplant, yet fewer than 18,000 of the 93,000 people on the transplant waiting list will actually receive an organ this year, and those who do are likely to need a replacement within 10 years.

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  1. William Aquino William Aquino United States says:

    I have been on Home Hemodialysis using NXSTAGE equipment.  I will gladly volunteer for IMPLANTABLE DEVICE abdomen dialysis anytime....

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