Study examines public health impact of tamper resistant extended-release oxycodone

Published on November 16, 2012 at 6:44 AM · No Comments

This is the first epidemiological study to examine the public health impact of a tamper resistant extended-release oxycodone (ORF). ER oxycodone was reformulated with physicochemical barriers to crushing and dissolving intended to reduce abuse through non-oral routes of administration. Manufacturer shipments of original ER oxycodone stopped on August 5, 2010, and ORF shipments started August 9, 2010. During the first 20 months following ORF introduction, it was abused significantly less than the original ER oxycodone when measured by 8 outcome measures, particularly through non-oral routes of administration that require tampering (such as injection, snorting, smoking).

More information on this study can be found in the article, "Abuse rates and routes of administration of reformulated extended-release oxycodone: initial findings from a sentinel surveillance sample of individuals assessed for substance abuse treatment" published in the November 2012 issue of the Journal of Pain.

A sentinel surveillance sample of 140,496 individuals assessed for substance abuse treatment at 357 treatment assessment centers across the country between June 1, 2009 and March 31, 2012 was examined for abuse through oral and non-oral specific routes of administration for ER oxycodone before and after ORF was introduced. Significant reductions were observed in eight outcome measures of ORF versus the original ER oxycodone. Data were collected by Inflexxion's proprietary NAVIPPRO- (National Addictions Vigilance Intervention and Prevention Program) system, which includes a network of hundreds of substance abuse assessment centers in the US. The NAVIPPRO data monitoring system tracks prescription opioid and stimulant drug abuse patterns and estimate relative rates of abuse of specific prescription products.

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