Multipotent stem cells in deer antler may have regenerative uses in veterinary medicine

Published on March 20, 2013 at 1:55 PM · No Comments

A team of researchers in Seoul, Korea have reported finding evidence that deer antlers - unique in that they regenerate annually - contain multipotent stem cells that could be useful for tissue regeneration in veterinary medicine.

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0897seo.

"We successfully isolated and characterized antler tissue-derived multipotent stem cells and confirmed that the isolated cells are self-renewing and can differentiate into multiple lineages," said study co-author Dr. Kyung-Sun Kang of the College of Veterinary Medicine at Seoul National University. "Using optimized culture conditions, deer antler displayed vigorous cell proliferation."

Deer antler has been an issue in the news recently when professional athletes allegedly therapeutically used deer antler sprays, said to contain the insulin-like growth factor, IGF-1, to recover from injuries. The Korean research team did not investigate the potential for deer antler to be used in human therapies, but suggested that it could be used in veterinary medicine due to the impact of two important factors; the regenerative and the proliferative capabilities of the stem cells they isolated.

Stem cells, cells with the capability to differentiate into varieties of cells, have been isolated from a number of tissues, including bone marrow, fat tissues, umbilical cord blood, placenta and menstrual blood. Stem cell research in the last two decades has focused on both pluripotent stem cells, able to differentiate into all cell types of the body, and multipotent stem cells, able to differentiate into some but not all cell types, the latter of which has a longer history of study as they were identified earlier.

Researchers have sought to use transplanted stem cells for many regenerative purposes - from using them to regenerate neural cells following stroke or spinal cord injuries, to using stem cells to help regenerate failing or injured organs.

Deer antler is of interest, said the researchers, "because antlers are very peculiar organs in that they are lost and re-grown annually-.a rare example of a completely regenerating organ in mammals."

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