Researchers study specific bacteria that contribute to overactive bladder

Thousands of women suffer from overactive bladder (OAB) or the sudden need to urinate, yet many don't get relief from medication. Researchers at Loyola University Health System believe certain bacteria may be to blame.

Loyola has launched a clinical trial to determine if the bacteria present in the urine of women who respond to treatment for overactive bladder are different than those who do not respond.

"Overactive bladder can be caused by a number of issues, which may explain why medication works for some and not others," said Linda Brubaker, MD, a urogynecologist at Loyola University Health System and dean of Loyola University Chicago Stritch School of Medicine. "If we can identify differences in the bacteria in women who respond to treatment and those who do not, we can better manage these patients and improve their quality of life."

OAB is a socially debilitating disease that may result from various issues, including cancer or neurological diseases. Urinary tract infections also lead to symptoms of OAB with the difference being bacteria.

"Certain bacteria in the urine may contribute to urinary symptoms," Dr. Brubaker said. "While further research is needed, women with these bacteria may benefit from antibiotics rather than traditional treatments for OAB."

Loyola researchers are looking to recruit women for this study. Study participants will complete a questionnaire and will undergo a series of screening procedures.

Women involved in the study also will provide urine samples, which researchers will evaluate with traditional cultures and DNA-based detection measures to identify the bacteria present.

Source: Loyola University Health System