Glucose monitoring systems with an autocorrect feature that can detect red blood cells (hematocrit), vitamin C and other common interferents in burn patients' blood are better for monitoring care, a pilot study conducted by UC Davis researchers at the School of Medicine and College of Engineering has found. The study was published in the Journal of Burn Care Research.
Burn patients are at risk for high blood glucose levels, or hyperglycemia, due to the body's stress response. Intensive insulin therapy, which is commonly used to keep glucose under tight control, significantly reduces mortality and morbidity. But not all glucose monitoring systems are created equal, according to Nam Tran, assistant adjunct professor of pathology and laboratory medicine at UC Davis and lead author of the study.
"Many glucose monitoring systems, including those used throughout the five University of California health systems, may not adequately correct for interferents in the blood of burn patients," Tran said. "As a result, an inaccurate reading increases the potential for an insulin overdose. Our study showed that using a device that autocorrects for interferents can produce more accurate blood glucose measurements, which can improve insulin dosing and glucose control."
A multidisciplinary team of faculty and student researchers from the Department of Pathology and Laboratory Medicine, Department of Biomedical Engineering, and the Department of Surgery conducted the study by assessing two different commercially available glucose monitoring systems in UC Davis' Firefighters Burn Institute Regional Burn Center.
Based on the researchers' findings, UC Davis patients at risk of hematocrit and vitamin C interferences, especially burn patients receiving high dose vitamin C therapy, will now be tested for glucose levels with the hospital's clinical chemistry laboratory analyzer. Tran is working with the UC Davis Clinical Laboratory staff to install a flag notification in the electronic health record system to notify physicians about utilizing the hospital's laboratory analyzer for these high-risk patients.
Traditional hospital lab testing uses plasma (samples devoid of red blood cells), so it remains the most accurate method for measuring blood glucose levels. However, the newer autocorrecting devices use less blood, essentially one drop, and produce results in just five seconds, as opposed to approximately 10 to 20 minutes for lab testing.
"In a critical burn patient, glucose levels can change even within that small time frame," Tran said. "A glucose monitoring system that can autocorrect is a necessary requirement to improve the quality of patient care."
Future studies will evaluate the performance of the autocorrection features of newer glucose meters. and assess whether autocorrection provides the most accurate glucose monitoring for all patient populations.
Tina L. Palmieri, professor of surgery and director of the Firefighters Burn Institute Regional Burn Center at UC Davis, is enthusiastic about the findings.