Radiofrequency ablation (RFA) leads to remission for 91 percent of patients with dysplastic Barrett's esophagus, according to new figures published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. Dysplastic Barrett's esophagus is the most serious grade of the condition in which precancerous cells are detected in the esophagus.
"In order to make appropriate informed decisions about the use of radiofrequency ablation, patients and providers need to be well versed in the risks and benefits of the procedure," said Nicholas J. Shaheen, MD, MPH, AGAF, study author from the Center for Esophageal Diseases and Swallowing at the University of North Carolina School of Medicine. "This study fills an important gap in research by combining the results of several smaller studies. We now have dependable figures showing that radiofrequency ablation is a safe and effective treatment for most patients with dysplastic Barrett's esophagus."
Investigators conducted a systematic review and meta-analysis of reputable studies published in PubMed and EMBASE to determine trends among Barrett's esophagus patients with intestinal metaplasia (the first phase of the condition in which intestine-like cells develop in the esophagus) and dysplastic Barrett's esophagus. In addition to the high percentage of patients who achieved complete eradication of dysplasia, the investigators reported that complete eradication of intestinal metaplasia was achieved in 78 percent of patients.