Patients who experience abrupt kidney injury following surgery have an increased risk of later developing heart problems, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that properly treating and monitoring patients with acute kidney injury (AKI) could help protect their heart health.
AKI, an sudden decline in kidney function, is an increasingly prevalent and potentially serious condition in hospitalized patients. Sometimes acute kidney injury arises after major surgery because the kidneys can be deprived of normal blood flow during the procedure.
Relatively little attention has been paid to potential links between AKI and later heart problems. To investigate, Vin-Cent Wu, MD, PhD (National Taiwan University Hospital) and his colleagues analyzed information from hospitalized patients who recovered from AKI that required dialysis. Data were collected from inpatient claims of the Taiwan National Health Insurance from 1999 to 2008.
Among the 17,106 acute dialysis patients who were discharged, 4869 recovered from dialysis-requiring AKI and were matched with 4869 patients without AKI.
•The incidence rate of coronary events was 19.8 per 1000 person-years in the AKI-recovery group, compared with 10.3 per 1000 person-years in the non-AKI group. (A person-year is the number of years of follow-up multiplied by the number of people in the study.)
•Patients who recovered from AKI had a 67% increased risk of experiencing coronary events or dying during the study period, regardless of whether or not they developed chronic kidney disease.
•AKI's harmful effects on heart health were comparable to those attributed to diabetes.