Debilitating side effects associated with prescription medication for some of today's most common conditions could be eradicated if they mimicked the body's natural hormone secretion cycles, a new report has said.
Scientists from Exeter and Bristol have studied how conventional steroid treatments - commonly used to treat a range of conditions from steroid deficiency to inflammatory diseases such as asthma and arthritis - can have serious side effects due to the way in which they are delivered to the body.
The study concluded that many of these side effects could be significantly reduced if the delivery of the medication mimicked the timing of the body's own natural release mechanisms and that pharmaceutical companies should develop novel techniques for achieving this.
The report, which is published in the online medical journal Lancet: Diabetes and Endocrinology, has been co-authored by Professor John Terry, a mathematician from the University of Exeter and Professor Stafford Lightman, a clinical endocrinologist from the University of Bristol.
They focused on the dynamics of natural hormone secretion and subsequent effects on the brain and other organs. Combining mathematical modelling with the latest clinical and experimental data, they found that the body regulates the release of crucial steroid hormones (such as cortisol) in pulses approximately every hour.
In stark contrast to this, modern medications deliver replacement steroids in oral doses that gradually disperse throughout the body. This results in a pattern of hormone in the body totally different from the normal body rhythm, which can cause malfunction of many body systems that have evolved to respond to a dynamic pattern of hormone levels. Significantly, many conditions such as depression, post-traumatic stress disorder and sleep apnoea are also associated with disruptions to the body's internal rhythmic secretion of hormones.
Professor Terry, from Exeter's College of Engineering, Mathematics and Physical Sciences said: "The body secretes small amounts of steroid in pulses, and it is far better for science to work in harmony with this natural process than to override it.