Previous studies have shown that Yizhijiannao granule can enhance cognitive performance in Alzheimer's disease patients and Alzheimer's disease-model mice. Further studies revealed that Yizhijiannao granule may exert its therapeutic effect by inhibiting neural cell apoptosis, reducing tau phos-phorylation and relieving neuroinflammation. Dr. Hong Zhu and colleagues who come from Third Xiangya Hospital of Central South University, China treated senescence-accelerated mouse prone 8 mice with Yizhijiannao granule, aiming to identify target-proteins of Yizhijiannao granule that were particularly related to the treatment of Alzheimer's disease.
Thirty-seven differential protein spots were found in the temporal lobe area, and finally 10 protein spots were identified. These proteins are separately involved in the regulation of amyloid beta production, oxidative stress, neuroinflammation, regulation of tau phosphorylation, and regulation of neuronal apoptosis. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 13, 2014).