The cingulum is an important pathway for cholinergic innervation for the cerebral cortex. Many studies have reported connections between the cholinergic nuclei, especially between the cholinergic nuclei in the basal forebrain and those in the brainstem via the fornix and thalamus.
However, little is known about the connection between cholinergic nuclei in the basal forebrain and cholinergic nuclei in the brainstem via the cingulum. Even no study on this phenomenon after cerebral hemorrhage has been reported. Dr. Sung Ho Jang and team from College of Medicine, Yeungnam University in Korea report on a patient who showed unusual neural connections between injured cingulums and brainstem cholinergic nuclei following aneurysmal subarachnoid hemorrhage, using diffusion tensor tractography. The relevant article has been published in the Neural Regeneration Research.