EnGeneIC receives award from Cancer Institute NSW for groundbreaking cancer research

Multidisciplinary team composed of six organizations awarded $20,000 for groundbreaking work in mesothelioma and non-small cell lung cancer

EnGeneIC, Ltd., an emerging biopharmaceutical company focused on revolutionizing the treatment of cancer through the targeted delivery of therapeutic agents directly to cancer cells, announced that, together with the Asbestos Disease Research Institute (ADRI), it has received the 2014 Cancer Institute New South Wales (NSW) Premier’s Award for Excellence in Translational Cancer Research. The other four recipients are the hospitals that will be involved in the clinical trial, being the Royal Prince Alfred Hospital, Strathfield Private Hospital, Royal North Shore Hospital and Concord Repatriation General Hospital. The recipients will receive a $20,000 prize to go towards furthering their research on microRNA replacement therapy for the treatment of malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC).

The award, which was presented on August 22, 2014, recognized the multidisciplinary team of scientists, clinicians and biotech experts for rapidly bringing their research in MPM into the clinical trial stage in less than three years. The MesomiR-1 trial is the first trial to focus on MPM and NSCLC and represents a promising new approach against these cancers.

Himanshu Brahmbhatt, Ph.D., joint-CEO of EnGeneIC, stated:

There is a significant medical need to develop new therapies aimed at treating MPM and NSCLC. The findings from this research have also led to the development of a promising treatment strategy using EnGeneIC’s EDV™ nanocells to replenish the lost family of microRNAs in MPM tumor cells.

Tumor samples stored in the ADRI mesothelioma biobank, one of Australia’s largest repositories of tumor samples, were analysed by Dr. Glen Reid and Professor Nico van Zandwyck of the ADRI. They discovered that an entire microRNA family, the miR-15/16 group, was lost in MPM tumor cells. When these microRNAs was restored using EnGeneIC’s bacterially-derived and antibody-guided EDV™ nanocells, the researchers at EnGeneIC and ADRI observed growth inhibition in the MPM cells in a mouse xenograft model.

Jennifer MacDiarmid, Ph.D., joint-CEO of EnGeneIC, added:

We are very honored to receive this prestigious research award from the NSW Cancer Institute. This recognition demonstrates that our proprietary EDV™nanocell platform is a truly enabling technology which allows microRNA replacement therapy in serious cancers like MPM.