Creative Diagnostics announces launch of antibody generation service based on DNA immunization technology

Creative Diagnostics, the global diagnostics service and product supplier, is pleased to announce its launch of custom antibody production service based on DNA immunization technology. This DNA immunization technology allows high success rate in generation of high-affinity antibodies recognizing difficult-to-express proteins in their native confirmation, such as GPCRs, ion channels and other multiple membrane spanning proteins.

Creative Diagnostics was established in 2005, in New York, as a global antibody products and antibody related services supplier, with more than ten years of commitment to providing high quality monoclonal antibody and polyclonal antibody products and services. With the purpose to become the world leading antibody products and service supplier, the company has been constantly expanding its services over years.

Antibodies remain a vital tool for the detection of proteins in basic research and diagnostics. To generate such antibodies, conventional immunization methods require the isolation and purification of the protein of interest, an often difficult and time-consuming task that is distracting from the real research objective.

Genetic immunization is an attractive approach to generate antibodies because native proteins are expressed in vivo with normal posttranscriptional modifications, avoiding time-consuming and costly antigen isolation or synthesis. And DNA Immunization technology is a powerful tool to aid in custom antibody production against membrane proteins, other problematic antigens, as well as early DNA vaccine development studies. The unique antibody development approach involves direct immunization of host animals with plasmid DNA encoding the target protein of interest.

With years of preparation and introduction of new technical platforms, now Creative Diagnostics can offer proprietary genetic immunization based polyclonal and monoclonal antibody generation services.

"The DNA immunization technology we utilize is not only an innovative tool in antibody development against membrane proteins and other problematic antigens, but also a powerful technique in the early phases of DNA vaccine development. Creative Diagnostics' proven DNA immunization service can also facilitate customers in DNA vaccine development project," said Jessica Waldorf, Chief Scientific Officer of Creative Diagnostics.