Prescription stimulants safe for treating ADHD, study finds

A University of Michigan study appearing in JAMA Network Open found that that’s not the case. Researchers report that high school seniors who used stimulant therapy are no more likely to use cocaine or methamphetamine as young adults (ages 19-24) than peers who did not use stimulant therapy to treat ADHD as teenagers.

These findings should be comforting to parents who have teenagers taking stimulants for ADHD, who worry that these medications may lead to use of illicit stimulants like cocaine or methamphetamine as their children enter young adulthood and become more independent.”

Sean Esteban McCabe, lead researcher, U-M professor of nursing and director of the Center for the Study of Drugs, Alcohol, Smoking and Health

However, the study also found that teens who misuse prescription stimulants are significantly more likely to use cocaine or methamphetamine as young adults--and the frequency of misuse matters:

• 20% of teens who misused prescription stimulants during high school started using cocaine or methamphetamine in young adulthood
• 34% of teens who misused prescription stimulants 10 or more times used cocaine or methamphetamine as young adults

Taken together, the findings reinforce the importance of risk-reduction strategies such as monitoring and safely storing stimulant medications, as well as screening adolescents for drug use, including using prescription stimulants on their own, McCabe said.

The study is important, he said, because prescriptions for stimulant medications have greatly increased in the last two decades.

Prescription stimulants are the most commonly misused controlled substance among teens and young adults. Stimulant-related overdose deaths have increased tenfold in the past decade, according to data from the Centers for Disease Control and Prevention.

“Those overdose deaths are driven primarily by illicit stimulants such as cocaine and methamphetamine, calling into question the role that prescription stimulants might play in the initiation of illicit stimulants,” McCabe said. “We were interested in studying this association so we can identify and address drug use before major problems develop.”

Prior research has shown that ADHD is associated with an increased risk for illicit drug use, so the fact that researchers didn’t see an increased risk in teens who used stimulant therapy to treat their ADHD was encouraging.

Researchers used data from more than 5,000 high school seniors between 2005-2017 from U-M’s Monitoring the Future study, and followed these teens into young adulthood between 2011-2021. The MTF study is a national survey funded by the National Institute on Drug Abuse, part of the National Institutes of Health, that measures drug and alcohol use and related attitudes among adolescent students nationwide.

Co-authors included Vita McCabe, Philip Veliz and the late John Schulenberg of U-M; Timothy Wilens of Harvard Medical School; and Ty Schepsis of Texas State University,

Research reported in this news release was supported by the National Institute on Drug Abuse of the National Institutes of Health under award numbers R01DA001411, R01DA016575, R01DA031160, R01DA036541, UH3DA050173, and UH3DA050252, and by a research award 75F40121C00148 from the U.S. Food and Drug Administration. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.