Computational predictive toxicology services available in SafeBridge Consultants

SafeBridge Consultants, Inc.("SafeBridge"), a division of Trinity Consultants, Inc., Dallas, TX, with offices in Mountain View, CA, New York, NY, and Liverpool, UK, announces the availability of computational predictive toxicology services to the biopharmaceutical and chemical industry. With increasing numbers of potential chemical impurities in drugs, foods, cosmetics and consumer products, computational tools have become an integral part of safety assessment and enable higher throughput and successful risk prioritization strategies.

SafeBridge is an authorized user of Derek Nexus from Lhasa Ltd. of Leeds, UK, a knowledge-based expert system for the prediction of toxicological hazard, and Leadscope^® from Leadscope, Inc. of Columbus, Ohio, a statistical predictive quantitative structure-activity relationships ("QSAR") model.

SafeBridge will be able to apply these two software packages to:

• Assist pharmaceutical and chemical companies to meet the proposed International Conference on Harmonization ("ICH") M7 "Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals to Limit Potential Carcinogenic Risk" guideline;
• Conduct risk assessments of extractable and leachable chemicals into drug products;
• Assess the potential toxicity of contaminants in drugs, cosmetics, and other products for endpoints such as sensitization, nephrotoxicity, and reproductive effects; and
• Assist in chemical synthetic process development.

Source: SafeBridge