Fibrosis - What is Fibrosis?

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This is as opposed to formation of fibrous tissue as a normal constituent of an organ or tissue. Scarring is confluent fibrosis that obliterates the architecture of the underlying organ or tissue.

The term is also sometimes used to describe a normal healing process, but this usage is less common.

Examples of fibrosis include:

  • Pulmonary fibrosis (lungs)
    • Idiopathic pulmonary fibrosis (where the cause is unknown)
    • Cirrhosis (liver)
    • Endomyocardial fibrosis (heart)
    • Mediastinal fibrosis (soft tissue of the mediastinum)
    • Myelofibrosis (bone marrow)
    • Retroperitoneal fibrosis (soft tissue of the retroperitoneum)
    • Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis
    • Nephrogenic systemic fibrosis (skin)
    • Crohn's Disease (intestine)
    • Keloid (skin)
    • Old myocardial infarction (heart)
    • Scleroderma/systemic sclerosis (skin, lungs)

Further Reading

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  1. Shrishti Thakur Shrishti Thakur India says:

    What does Fibrotic opacities mean? What are the causes for this ? and what is the treatment for this ? please help.

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