Sarcoidosis, also called sarcoid or Besnier-Boeck disease, is a systematic granulomatous inflammatory disease characterized by non-caseating granulomas (small inflammatory nodules).
Its cause is unknown. Granulomas most often appear in the lungs or the lymph nodes, but virtually any organ can be affected. Normally the onset is gradual.
Sarcoidosis may be asymptomatic or chronic and may cause death.
Sarcoidosis may be divided into the following types:
- Annular sarcoidosis
- Erythrodermic sarcoidosis
- Ichthyosiform sarcoidosis
- Hypopigmented sarcoidosis
- Löfgren syndrome
- Lupus pernio
- Morpheaform sarcoidosis
- Mucosal sarcoidosis
- Papular sarcoid
- Scar sarcoid
- Subcutaneous sarcoidosis
- Systemic sarcoidosis
- Ulcerative sarcoidosis
Sarcoidosis most commonly affects young adults of both
sexes, although studies have reported more cases in females. Incidence
is highest for individuals younger than 40 and peaks in the age-group
from 20 to 29 years; a second peak is observed for women over 50.
Sarcoidosis occurs throughout the world in all races with an
average incidence of 16.5/100,000 in men and 19/100,000 in women.
disease is most prevalent in Northern European countries, and the
highest annual incidence of 60/100,000 is found in Sweden and Iceland.
In the United States, sarcoidosis is more common in people of African
descent than Caucasians, with annual incidence reported as 35.5 and
Sarcoidosis is less commonly reported in
South America, Spain, India, Canada, and Philippines.
The differing incidence across the world may be at least
partially attributable to the lack of screening programs in certain
regions of the world and the overshadowing presence of other
granulomatous diseases, such as tuberculosis, that may interfere with
the diagnosis of sarcoidosis where they are prevalent.
There may also be differences in the severity of the disease
between people of different ethnicity. Several studies suggest that the
presentation in people of African origin may be more severe and
disseminated than for Caucasians, who are more likely to have
Manifestation appears to be slightly different according to
race and sex. Erythema nodosum is far more common in men than in women
and in Caucasians than in other races. In Japanese patients,
ophthalmologic and cardiac involvement are more common than in other
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Last Updated: Aug 13, 2013