Idera Pharmaceuticals, Inc. (Nasdaq: IDRA), today announced the presentation of final data from a clinical trial evaluating IMO-2055, an agonist of Toll-like Receptor (TLR) 9, as monotherapy in patients with Renal Cell Carcinoma (RCC). The data are being presented during the Eighth International Kidney Cancer Symposium being held in Chicago, September 25-26, 2009.
In this phase 2 open-label, non-controlled clinical trial, treatment-naïve and second-line patients with RCC were randomly assigned to receive IMO-2055 subcutaneously at 0.16 mg/kg/week or 0.64 mg/kg/week. 89 patients were evaluable for efficacy (intent-to-treat population).
“This clinical trial of IMO-2055 monotherapy in RCC has provided us data that have been helpful in developing the strategy for clinical studies of IMO-2055 in combination with approved anti-cancer agents. Currently IMO-2055 is being evaluated in combination with Tarceva® and Avastin® in non-small cell lung cancer and in combination with Erbitux® and a Camptosar®-containing regimen in colorectal cancer,” said Alice Bexon, MBChB, Vice President of Clinical Development. “As previously announced, the primary objective based on RECIST was not achieved in this trial; however, we are encouraged by the progression-free survival compared to published reports with interferon alpha treatment. We have seen prolonged treatment durations in several patients.”
Based on the final data analysis: