CANCER RESEARCH UK SCIENTISTS have discovered a completely new route by which leukaemia develops, according to research published in Nature.
Scientists from the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge studied a gene called JAK2 which is faulty in many cases of leukaemia - but until now its role was not clear.
They discovered that if JAK2 is faulty, the cell's meticulously controlled message system 'short circuits'. As a result many genes are switched on and off inappropriately and a completely new cell signalling route by which leukaemia can develop is turned on.
The scientists found that the enzyme made by the JAK2 gene - is also located inside the cell nucleus and plays an important role to control how genetic information is used by the cell. Previously it was only known to be located on the inner surface of cells - acting as a messenger between the outside of the cell and the cell's nucleus.
The team discovered that the JAK2 enzyme acts in the nucleus to switch on and off a number of genes. It does this by changing the structure of histones - the proteins that pack and protect DNA - and which control the behaviour of many genes. The garbled messages from the faulty JAK2 gene lead to mis-management of histones which results in catastrophic effects on the workings of a cell.