Amarillo Biosciences, Inc. (ABI) (OTCBB: AMAR) today announced that Professor Dr. Otto Haller from the Department of Virology, Freiburg University, Germany and Professor Dr. Oliver Planz from the Friedrich Loeffler Institute, Tubingen, Germany gave two separate presentations on the efficacy of interferon to combat influenza. The presentations were made at the National Symposium for Zoonosis Research, held in Berlin, Germany October 7-8, 2009. Dr. Haller's presentation was entitled, "Interferons as emergency antiviral agents against highly pathogenic influenza A viruses: efficacy evaluation in animal transmission models," and Dr. Planz's presentation was named "H5N1 and swine-origin H1N1 influenza A viruses are susceptible to interferon type I treatment in vitro and in vivo."
Dr. Haller reported on the efficacy of interferon against influenza in the ferret animal model. Because the ferret shows symptoms that closely resemble influenza illness in humans, the ferret is considered to be a good model for human influenza. Dr. Haller reported that pre-treatment with interferon given intranasally was as beneficial as Tamiflu at reducing clinical symptoms and cell counts in the nasal washes of ferrets that were subsequently infected with influenza virus.
Dr. Planz reported that as little as one intranasal administration of low-dose interferon reduced the concentration of influenza virus in the lungs of treated mice. Furthermore, multiple intranasal administrations of low-dose interferon protected mice against otherwise lethal influenza infections. There was no evidence of toxicity in mice given low-dose interferon.
These results agree with the published report of Dr. Manfred Beilharz and colleagues at the University of Western Australia in Perth, who showed that giving a low dose of interferon once a day by mouth protected mice from a fatal influenza infection. Using a colored dye, researchers have found that oral and intranasal dosing both result in equal coating of the mouth and throat in mice. Both routes of administration should therefore be equally effective at delivering interferon to receptors located throughout the mouth and throat in order to boost the immune system. ABI is pursuing oral administration of interferon as it is more convenient for patients than a nasal spray.