Discovery may also have impact on the use of new drugs for wet macular degeneration
Scientists at Schepens Eye Research Institute have found that when the eye is missing a diffusible form of vascular endothelial growth factor (VEGF), i.e. one that when secreted can reach other cells at a distance, the retina shows defects similar to "dry" macular degeneration, also called geographic atrophy (GA). This finding, published in the November 3, 2009 print edition of PNAS (Proceedings of the National Academy of Sciences), not only increases the understanding of the causes of this blinding disease, but it may also impact the use of anti-VEGF drugs, such as Lucentis, which are designed to neutralize VEGF in eyes with "wet" macular degeneration.
"These results are significant for several reasons. We know little about what causes GA or how to treat it. Our discovery may be an important piece of the puzzle. It shows that reduced VEGF from the retinal pigment epithelium (RPE), the bottommost layer of the retina, to the choriocapillaris (CC) - the small blood vessels beneath retina-- leads to degeneration of the CC. Therefore, the continuous blockage of VEGF may contribute to the development of or a worsening of GA," says Patricia D'Amore, principal investigator of the study and senior scientist at Schepens.
VEGF is a protein that stimulates the growth of new blood vessels. The eye produces several different forms of VEGF that differ in their size and their ability to move away from the producing cell.