Exelixis, Inc. (Nasdaq: EXEL) announced today that thirteen abstracts related to the company’s development candidates have been accepted for presentation at the 2009 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, which is being held November 15-19 in Boston. Interim data from ongoing phase 1 clinical trials of XL147 and XL765 will be reported in four poster presentations. Exelixis is co-developing XL147 and XL765 in collaboration with sanofi-aventis. Clinical data for an ongoing phase 1 trial of XL139, which is being co-developed with Bristol-Myers Squibb, will also be reported. Other poster presentations will cover a variety of preclinical data and preclinical and clinical biomarker data for six compounds.
Clinical Data Presentations
- A phase 1 safety and pharmacokinetic (PK) study of PI3K/TORC1/TORC2 inhibitor, XL765 (SAR245409), in combination with erlotinib in patients (pts) with advanced solid tumors will be presented on Monday, November 16, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #A254)
- A first-in-human, phase 1 study of an oral hedgehog pathway antagonist, BMS-833923 (XL139), in subjects with advanced or metastatic solid tumors will be presented on Monday, November 16, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #A55)
- A phase 1 safety and pharmacokinetic (PK) study of the PI3K inhibitor XL147 (SAR245408) in combination with paclitaxel (P) and carboplatin (C) in patients with advanced solid tumors will be presented on Tuesday, November 17, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #B247)
- A phase 1 safety and pharmacokinetic study of XL765 (SAR245409), a novel PI3K/TORC1/TORC2 inhibitor, in combination with temozolomide (TMZ) in patients (pts) with malignant glioma will be presented on Tuesday, November 17, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #B265)
- A phase 1 safety and pharmacokinetic (PK) study of the PI3K inhibitor XL147 (SAR245408) in combination with erlotinib in patients with advanced solid tumors will be presented on Wednesday, November 18, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #C197)
Biomarker Data Presentations
- Pharmacodynamic and correlative biomarker analyses in clinical trials of XL184, an oral, potent inhibitor of MET, VEGFR2, and RET will be presented on Tuesday, November 17, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #B269)
- Characterization of the target profile of XL228, a multi-targeted protein kinase inhibitor in phase 1 clinical development will be presented on Wednesday, November 18, 2009, during the 12:30 pm – 2:30 pm poster session (Abstract #C192)
To access the clinical data posters mentioned in this press release, please visit www.exelixis.com. Please note that the clinical data posters will be available at time of presentation.
Preclinical Data Presentations