ImmunoGen reports encouraging clinical data of IMGN901

Published on December 6, 2009 at 11:57 PM · No Comments

ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics, today reported encouraging clinical data with its IMGN901 product candidate in the treatment of relapsed and relapsed/refractory multiple myeloma (MM), including prolonged benefit in patients whose disease had progressed on multiple prior treatment regimens. These findings were reported at the American Society of Hematology (ASH) 51th Annual Meeting and Exposition being held in New Orleans, MA.

IMGN901 is an investigational agent designed to kill cancer cells that express CD56, a protein. It consists of a CD56-binding antibody with a potent cancer-cell killing agent, DM1, attached to it using an engineered linker. IMGN901 is in Phase I testing for the treatment of CD56-expressing solid tumors and multiple myeloma. It is wholly-owned by ImmunoGen.

In the trial reported today, new cohorts of patients received increasingly greater amounts of IMGN901 – used as a single agent – until the maximum tolerated dose was established. All of the patients had CD56-expressing MM that had progressed on multiple therapies, and most had previously been treated with at least six chemotherapy regimens.

“What was particularly impressive was the duration of benefit seen with IMGN901 in a number of these heavily pre-treated patients,” commented Asher Chanan-Khan, MD, of the Roswell Park Cancer Institute. “IMGN901 demonstrated encouraging activity as a single agent in a disease often treated with combination therapy, and the tolerability findings to date support evaluating it used together with other active agents.”

Among the twenty-six patients treated with IMGN901 at any dose level:

  • One patient had a partial response (PR) while receiving IMGN901. This patient has continued on treatment for more than a year.
  • Three patients had a minimal response (MR) while receiving IMGN901, and two of these patients remained on treatment for at least 45 weeks. The third patient withdrew from the study due to a broken leg while continuing to show disease improvement.
  • Eleven patients had stable disease (SD), with eight of these patients remaining on treatment for at least 12 weeks at the time of data cut-off for presentation. These include four patients who have received IMGN901 for at least 24 weeks and two other patients still undergoing treatment.
  • The overall clinical benefit rate (objective responses plus sustained stable disease) was 46%.

Ten patients remained on IMGN901 longer than on regimens received earlier in the course of their disease, and eight of these patients were on IMGN901 longer than on their last regimen with approved therapies. Typically in the treatment of cancer, patients have their best treatment responses early in the course of their disease and respond less well to later therapies.

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