Mayo researchers collaborating with investigators at the University of Iowa, University of Connecticut and New York University (NYU) have discovered a molecular mechanism that controls energy expenditure in muscles and helps determine body weight. Researchers say this could lead to a new medical approach in treating obesity. The findings appear in the journal Cell Metabolism.
The energy-saving mechanism is controlled by ATP-sensitive potassium (KATP) channels. ATP, or adenosine triphosphate, is the "energy currency" utilized by cells in the body. These particular channels can sense ATP pools and regulate heart and skeletal muscle performance accordingly. Animals lacking this energy-saving mechanism burn more stored energy by dissipating more heat when at rest or when normally active.
As in humans, excess energy from food is stored as glycogen or fat that could be converted into ATP according to energy demand. Eliminating the KATP channel forces the body to use energy less efficiently, consuming more and storing less gaining low weight, even when on a high-calorie "Western" diet.
"While mechanisms that preserve energy are naturally protective - in times of food shortage or environmental stress - they promote obesity in a sedentary, modern society," says Alexey Alekseev, Ph.D., Mayo Clinic electrophysiologist and first author of the study. "Our findings suggest that therapeutic targeting of the KATP channel function, specifically in muscle, could offer a new option for obese patients with lower capacity for exercise."
How the study was done