Results of randomized, placebo-controlled study of Ambrotose complex announced

Mannatech, Incorporated (NASDAQ: MTEX), a global pioneer in the development of high-quality health, weight and fitness, and skin care solutions based on nutritional science, announced the results of a randomized, double-blind, placebo-controlled study that shows healthy middle-aged adults who took one teaspoon of Ambrotose^® complex twice daily performed significantly better on memory tasks and were overall more positive in their mood.

“The significantly better performance on memory tasks and positive effects on mood experienced by the study participants who consumed Ambrotose complex is congruent with beneficial effects on brain functions.”

Drs. Talitha Best and Eva Kemps of Flinders University in Adelaide, Australia, and Dr. Janet Bryan of the University of South Australia in Adelaide, Australia, published their findings of the 12-week study in the January 2010 issue of Developmental Neuropsychology, a peer-reviewed scientific journal.

“This rigorous double-blind, placebo-controlled study confirms important biological effects of Mannatech's flagship and proprietary product, Ambrotose complex,” said Dr. Robert A. Sinnott, MNS, PhD, co-chief executive officer and chief science officer of Mannatech. “The significantly better performance on memory tasks and positive effects on mood experienced by the study participants who consumed Ambrotose complex is congruent with beneficial effects on brain functions.”

The abstract of the study states that: “Before and after this supplementation period, participants completed alternate forms of standardized tests of cognition and self-report measures of well-being. Significant beneficial and longer-term effects of saccharide supplementation were found for memory performance and indicators of well-being. The potential for these nutrients to optimize cognitive function and well-being in older adults warrants on-going investigation.”

“Right now, commercial development of compounds to enhance cognitive functioning is one of the hottest areas of biomedical research,” Sinnott continued. “While most research focuses around synthetic compounds, Mannatech's Ambrotose complex is comprised of ingredients that are isolated and purified from renewable natural sources, primarily plants. Mannatech has pioneered the field of nutritional glycobiology since 1996, and we will continue to be a leader in the future.”