The nonprofit American Botanical Council (ABC) has just published a monograph summarizing selected scientific and clinical studies of Pycnogenol®, a patented dietary ingredient from French maritime pine bark.
Seventeen human clinical studies of Pycnogenol are reviewed in the monograph, evaluating the extract's potential benefits in numerous areas. These include its cardiovascular benefits, such as its ability to reduce difficulties associated with chronic venous insufficiency and problems related to thrombosis (formation or presence of blood clots in blood vessels).
Based on the review of scientific and clinical trials, the monograph notes that Pycnogenol has been shown to have a wide range of potential applications, including the ability to improve blood sugar control in patients with type 2 diabetes and improve endothelial function (the ability of blood vessels to widen through relaxation of the muscular wall of the vessels). Current clinical trial data suggest that Pycnogenol may also help decrease edema formation (swelling) in the lower legs, benefit children with attention deficit hyperactivity disorder (ADHD), be a useful adjunct therapy for patients with asthma, reduce pain associated with menstrual disorders, and improve subjective symptoms of osteoarthritis in the knee.
"Pycnogenol is an excellent example of a natural plant-based product which is the subject of extensive clinical research," said ABC Founder and Executive Director Mark Blumenthal. "ABC acknowledges Horphag Research, the manufacturer, for its singular focus and for its commitment to funding continued clinical trials to investigate and document the beneficial role Pycnogenol might have in selfcare and healthcare."
Horphag Research of Geneva Switzerland invests about $1.5 million annually in new scientific and clinical research on the special extract.
"The ABC monograph on Pycnogenol presents one of the most comprehensive and detailed monographs ever published on a dietary ingredient," said Victor Ferrari, CEO of Horphag Research. "Consumers, health professionals, and industry members alike are looking for comprehensive and evidence-based information, and as such, the monograph provides an excellent detailed view of the versatility of this natural product."
The monograph is published in three parts: The full monograph, a clinical overview (i.e. executive summary) containing condensed information from the monograph, and a consumer/patient information sheet, consisting of essential information for consumer education about the responsible use of the product. Each of these elements is accessible separately on the ABC website.
The full monograph contains an overview of Pycnogenol's production and chemistry, uses of the product, dosage information, summaries of the product's pharmacology and mechanisms of action, safety data, and summaries of selected clinical trials. A table includes synopses of the clinical trials profiled within the monograph's text, plus summaries of several additional studies. The monograph also includes how Pycnogenol is regulated in 10 countries and regions around the world.