As you age, your blood ages. Deep in your bone marrow, blood stem cells keep churning out your blood cells, but the mix of blood cell types goes awry, making you more prone to disease.
Joslin Diabetes Center scientists now have demonstrated that in old mice exposed to certain proteins that are present in blood from young mice, old blood stem cells begin to act like young ones—and this process is driven by signals from another type of cell nearby in the bone.
Published in a paper in Nature on January 28, the findings from researchers in the lab of Joslin Principal Investigator Amy J. Wagers, Ph.D., advance our understanding of aging of the blood-forming ("hematopoietic") system and point toward ways to treat age-related ailments via the blood.
Previous work by many labs gave evidence that the decline in blood stem cell function that comes with age is partly intrinsic to the cells themselves. However, these cells also are affected by signals from other cells in the local bone marrow microenvironment or "niche".
An earlier study led by Shane Mayack, Ph.D., a postdoctoral fellow in the Wagers lab, pinpointed bone-forming cells known as osteoblasts as key players in this signaling from the niche, and showed that osteoblasts play a particular role in blood stem cell maintenance and regeneration.
For the latest paper, Mayack and her colleagues studied the blood stem cell aging process in young and old mice. The researchers found that as osteoblasts age, they change the signals that they send to stem cells, and that this change makes those cells less able to produce the right mixture of blood cells.
More dramatically, in a series of tests in which two mice shared a common blood circulation, the scientists revealed that this aging mechanism could be reversed. In old mice paired with young mice, the existing populations of osteoblasts showed signs of rejuvenation. Remarkably, this rejuvenation was communicated to the stem cells as well, such that the blood-forming abilities of these aged mice took on much more "youthful" characteristics.