ZenBio awarded Phase I SBIR grant to establish novel human cell-based models of NAFLD

ZenBio, Inc. announced that it has been awarded a Phase I SBIR grant to establish novel human cell-based models of non-alcoholic fatty liver disease (NAFLD) that will be useful for basic research and as a potential drug development platform. The project stems from recent efforts at ZenBio, Inc. to develop methods for differentiating adipose tissue derived progenitor cells into hepatocyte-like cells. The current award from the National Institutes of Health will fund proof-of-concept studies that these human hepatocyte-like cells can be used to mimic the development of non-alcoholic fatty liver disease in cell culture.

Obesity and Type 2 diabetes affect the lives of millions of people worldwide. In parallel with the increasing incidence of obesity and insulin resistance is the occurrence of NAFLD, a chronic hepatic disorder that may be affecting up to 25% of the general population; including a significant portion of pediatric cases. Several intracellular events leading to NAFLD and progression to non-alcoholic steatohepatitis (NASH) have been identified. However, the exact molecular mechanisms require further investigation, especially in human systems. Primary human hepatocytes are the most physiologically relevant cell-based model for in vitro hepatic function. However, the availability of primary human hepatocytes for cell-based applications is significantly limited. In order to address the market demand for relevant human cell-based models of hepatocyte function, ZenBio, Inc. is developing an alternative model based upon the differentiation of adipose tissue derived adult stem cells (ASC) to hepatocyte-like cells. Bentley Cheatham, Ph.D. (ZenBio's vice-president of R&D) stated, "We have data suggesting that the ASC-derived hepatocytes possess many of the characteristics of primary human hepatocytes, and are in the process of developing applications of these cells for use in basic research applications, cell therapy and drug development. Specifically, this Phase I project will focus on the utility of this novel human model system for the study of NAFLD."