US scientists have shown that the Ginkgo extract EGb 761® promotes the formation of new nerve cells and new cell connections in the hippocampus, the brain's memory center. According to Professor Yuan Luo from the University of Maryland, Baltimore, the Ginkgo constituents responsible for these effects are quercetin and bilobalide.
“The results obtained by Professor Luo during the research projects sponsored by the US National Institutes of Health (NIH) are very interesting indeed. They attest emphatically to the effects of EGb 761® on extremely harmful Alzheimer changes in the brain and to quite fundamental processes in information processing”
"Our findings suggest that strengthened nerve-cell connections are a contributing factor to the beneficial effect of EGb 761® on cognitive functions. In Alzheimer-disease models the extract can stimulate the formation of fresh nerve cells and cell links. Our data therefore suggest that the extract can help improve cognitive decline in elderly people", explained Professor Luo at a press conference in Amsterdam.
Over recent years, Professor Luo initially demonstrated that Ginkgo extract EGb 761® considerably reduces the pressure on nerve cells caused by the extremely damaging deposits of abnormal protein molecules typical of Alzheimer's disease. The particularly vulnerable brain cells in the hippocampus region, which regulate access to memory and the further processing of information, were protected against damage and formed new cell connections: "We were able to show that Ginkgo extract EGb 761® directly inhibits the formation of toxic A-beta oligomers and stimulates the development of newly functional nerve cells in a mouse model of Alzheimer's disease", explained Professor Luo in Amsterdam. She continued: "It's well known that there is a proliferation of A-beta oligomers in the brains of Alzheimer patients and that they are responsible for the loss of nerve-cell connections."