Nanotherapeutics, Inc., announced that it has filed an Investigational New Drug (IND) Application with the Food and Drug Administration (FDA) for NanoDTPA™ an orally administered capsule that is a less invasive treatment alternative to the FDA approved injectable Zn-DTPA (diethylenetriamine pentacetic acid). DTPA is used to remove radioactive compounds from the body to help eliminate the contamination. The NanoDTPA™ capsule is a unique orally-bioavailable fine particle formulation that allows DTPA to be absorbed into the body from the gastrointestinal tract.
Nanotherapeutics began development of NanoDTPA™ with funding from the National Institutes of Health (NIH) and the Biomedical Advanced Research and Development Authority (BARDA) under a competitive program, Development of Improved DTPA for Radionuclide Chelation. While DTPA can be used for exposure to radioactive nuclear materials from a spill or "dirty bomb" attack, as an intravenous formulation, it is not practical for treating a widespread population. The NIH contracted with the company to develop a more practical easier-to-administer alternative.
Preclinical studies of NanoDTPA™ Zn-DTPA capsule demonstrated strong pharmacokinetic and safety profiles. The IND will allow the company to begin clinical trials of the capsule to determine dosing, safety, and efficacy of this alternative formulation. There is also potential for use of NanoDTPA™ for iron chelation to treat iron overload. (http://www.nanotherapeutics.com/products_pipeline.php)
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