Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today that it has initiated a Phase 2a clinical study of PRM-151 to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery. There currently are no approved drugs for preventing post-surgical scarring in glaucoma, and there are no approved anti-fibrotic drug therapies in the U.S. or Europe for any fibrotic disease.
“The initiation of this clinical trial represents important progress for Promedior as we believe that PRM-151 represents a novel and powerful first-in-class agent to prevent and treat fibrotic diseases”
Promedior's lead product, PRM-151, is a recombinant form of a naturally circulating human protein, Pentraxin-2 (PTX-2, also called human SAP), that regulates a fundamental mechanism of the innate immune system and activates the body's natural ability to resolve tissue damage in disease processes that cause fibrosis and inflammation. PRM-151 has shown broad anti-fibrotic and anti-inflammatory activity in multiple preclinical models of fibrotic disease and inflammation, including glaucoma, pulmonary fibrosis, and acute and chronic nephropathy. Promedior successfully completed a Phase 1 clinical study of PRM-151 earlier in 2010.