Lytix Biopharma, KAEL-GemVax initiate treatment in LTX-315/GV1001 combination anti-cancer vaccine trial

The Norwegian biopharmaceutical company Lytix Biopharma and the Korean biotechnology company KAEL-GemVax announced today the successful first treatment in the study of a combination of LTX-315 and GV1001 as anti-cancer vaccine therapy.

“We are very happy that the first patient has been vaccinated in our combination trial. There is a strong scientific rationale for combining these agents and we believe they should have potential to function as an efficient immunotherapy for the treatment of cancer”

According to Lytix Biopharma CEO Gunnar Sælid and KAEL-GemVax CEO Jay Sangjae Kim, "We are delighted to announce the inclusion of the first patient in our previously announced joint study to test LTX-315 as an adjuvant for the GV1001 anti-cancer peptide vaccine. LTX-315 causes release of cellular 'danger' signals triggering activation of the innate immune system, seems to create an optimal environment in which to generate strong immune responses towards peptide vaccines. GV1001 is a peptide anti-cancer vaccine in Phase III TeloVac trial, directed against the telomerase enzyme, and is one of the best documented therapeutic cancer vaccines currently in development. The telomerase-target for therapeutic vaccination is universally expressed in tumours, giving the LTX-315/GV1001 combination a potentially broad utility against a range of cancer types."

"We are very happy that the first patient has been vaccinated in our combination trial. There is a strong scientific rationale for combining these agents and we believe they should have potential to function as an efficient immunotherapy for the treatment of cancer", says Mr. Jon Amund Eriksen, Director of Development, Oncology at Lytix Biopharma. The clinical study is running at the University Hospital of Northern Norway in Tromsø, under clinical supervision of the Primary Investigator Dr. Tone Nordøy. The study will include approximately 20 patients and will document the safety, tolerability and anti-telomerase immune responses of GV1001 together with LTX-315.