BioInvent International AB (STO:BINV) announces today the dosing of the first patient in the phase II study of the Company's antibody, BI-204. The product candidate is being developed for secondary prevention of cardiovascular events in patients with acute coronary syndrome.
The Phase II study is a multicenter, randomized, double-blind, placebo-controlled study of BI-204, delivered intravenously to patients on standard-of-care therapy for stable atherosclerotic cardiovascular disease. The trial will enrol 120 patients at approximately 20 centres in the United States and Canada. It is designed to demonstrate a reduction in plaque inflammation following treatment as quantified by FDG-PET imaging (18F 2-deoxyglucose positron emission tomography).
The antibody is being developed in collaboration with Genentech, a member of the Roche Group (SIX:RO)(SIX:ROG)(OTCQX:RHHBY). BioInvent will receive a milestone payment of US$ 15 million from Genentech upon dosing of the first patient.
Svein Mathisen, CEO of BioInvent, commented: "BI-204 originates from BioInvent's proprietary n-CoDeR® library and it represents an innovative approach to potentially reducing cardiac events in patients with coronary heart disease. The results from this phase II clinical trial will provide further insights into BI-204's ability to reduce plaque inflammation and how it potentially can add to current treatment of coronary heart disease."
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