By Dr Ananya Mandal, MD
The Center for Disease Control and Prevention says that heart failure affects nearly 6 million Americans leading to considerable risk of death, diminished quality of like and recurrent hospitalizations. Heart failure occurs when the heart can no longer pump enough blood to the rest of the body. The most common cause of heart failure is coronary artery disease, which narrows the small blood vessels that supply blood and oxygen to the heart.
Stem cell therapy from another person
Promising results of a Phase II study on heart failure were presented Monday at an American Heart Association meeting in Orlando, Florida. The study, sponsored by Mesoblast Ltd. (MSB), found that patients with heart failure can now reduce future occurrences by as much as 80 percent using an experimental stem-cell treatment called Revascor, which is Mesoblast’s experimental drug. Revascor is derived from mesenchymal stem cells from another person.
The researchers included patients between the ages of 20 and 80 who were tracked for at least 12 months. In the study, 45 patients who have had previous history of moderate to severe congestive heart failure were give an shot of Revascor along with standard medicines. The negative control group had 15 people and didn’t receive the treatment.
Results showed that the therapy was safe and well-tolerated at all doses an overall risk of a major adverse cardiac event was cut by 78 percent. During the follow-up period of 22 months, one patient in the group receiving the Revascor treatment died, while three fatalities were recorded in the control group.
Researchers explain that mesenchymal stem cells have the ability to differentiate into any other cell depending on the cellular signals it receives. The underlying theory is that the stem cells will differentiate into cardiac cells and will repair the damaged areas affected by heart failure, thus improving the damaged heart’s ability to pump out blood.
Mesoblast representatives said that it expects to enter Phase III trials in the first half of next year. The treatment is projected to go on sale by 2015.
Stem cell therapy from one’s own body
In yet another study stem cells harvested from a patient's own heart were used successfully in repairing a failing heart. This study was based on the results from a trial presented this month at an event held by the American Heart Association.
The clinical trial, dubbed SCIPIO (Cardiac Stem Cell Infusion in Patients with Ischemic cardiOmyopathy), is in early-stage testing and is being conducted by Roberto Bolli of the University of Louisville and colleagues.