New research on bed bug's ability to withstand genetic bottleneck of inbreeding

Published on December 7, 2011 at 5:09 AM · 1 Comment

As bed bug populations spread throughout the United States, scientists at ASTMH meeting release new research on their biology and behavior

New research on the bed bug's ability to withstand the genetic bottleneck of inbreeding, announced today at the American Society of Tropical Medicine and Hygiene (ASTMH) annual meeting, provides new clues to explain the rapidly growing problem of bed bugs across the United States and globally. After mostly disappearing in the US in the 1950s, the common bed bug (Cimex lectularius) has reappeared with a vengeance over the past decade. These stubborn pests have developed a resistance to the insecticides, known as pyrethroids, commonly used against them.

Scientists at ASTMH also offered new insights into infestations in apartment buildings and homes; a novel approach for preventing insecticide resistance; and new information about chemical compounds involved in attracting and repelling bed bugs.

While these blood-sucking parasites don't transmit disease, their bites provoke allergic reactions-including inflamed welts and severe itching-and they pose both a social and economic threat to owners and residents of apartment buildings, hotels and public buildings. The financial impact has been substantial.

"New York City alone spends between $10 million and $40 million per year on bed bug control, and these numbers are repeated in other major cities across the US," noted Rajeev Vaidyanathan, PhD, associate director of Vector Biology and Zoonotic Disease at SRI International. "Over 95 percent of pest control agencies reported bed bugs as a priority in 2010, thus superseding termites as the number one urban pest." The number of reported bed bug infestations in single family homes, hotel rooms and multi-unit housing has increased 10- to 100-fold since those recorded in 1990. Many reasons behind the increases are poorly understood.

One of the newly discovered factors that appears to be contributing to the bed bugs' effective infestation is their ability to establish new infestations through inbreeding. Coby Schal, PhD, and Ed Vargo, PhD, both entomologists at North Carolina State University (NCSU), and colleagues carried out two studies now under peer-review examining the genetics of bed bugs from three multi-story apartment buildings in North Carolina and New Jersey, and determined that there were high levels of relatedness within each apartment and very low genetic diversity within each building, indicating that infestations start from just one or two introductions of the insect. Being able to withstand a very high level of inbreeding-i.e., still produce healthy offspring-allows the bed bug infestation to expand to other apartments within the building.

Another study by this team confirmed this same conclusion based on a study of 21 bed bug infestations from Maine to Florida in the US, nearly all of which came from single rooms within homes. "Inbreeding gives bed bugs an advantage in being able to colonize," said Schal. "A single female that has been mated is able to colonize and start a new infestation. Her progeny and brothers and sisters can then mate with each other, exponentially expanding the population. With many organisms, extensive inbreeding would cause serious mutations that would eventually bring about an end to the population." He also noted that cockroach populations are also able to survive inbreeding.

Overcoming Insecticide Resistance

Further evidence of such resilience has been observed in the bed bugs' resistance to previously successful insecticide strategies. However, new research has revealed that it is possible to "shut down" the mechanism that is linked to breaking down the insecticide and making the bed bug resistant to pyrethroid insecticides.

For the last five years, entomologist Ken Haynes, PhD, and colleagues at the University of Kentucky have been focused on insecticide resistance in bed bugs. He and his colleagues, Subba Reddy Palli and Fang Zhu, looked at a way to eliminate this resistance by targeting specific enzymes inside bed bugs associated with the P450 detoxification system that destroy the insecticides before they reach their molecular target. Rather than attempting to knock out all of the enzymes in the system, the scientists used RNA interference against an enzymatic partner of the P450 family to selectively turn off the system inside bed bugs and preserve the utility of the insecticide-in this case deltamethrin.

Building Better Detectors and Traps

Other potential options for controlling bed bug populations may lie in identifying and understanding the function of chemical compounds secreted by the pests. The researchers revealed that they are still finding new compounds that influence bed bug behavior. Vaidyanathan's group recently isolated seven new compounds that had never been identified from bed bugs that might serve as bed bug attractants. The researchers noted that it might be possible to develop a trap with a "cocktail" of these bed bug compounds to attract the pests.

Mark Feldlaufer, PhD, an entomologist with the US Department of Agriculture's Agricultural Research Service, is working to better understand the underlying mechanisms of the chemical factors, or pheromones that affect bed bug behavior. He has examined the chemical blueprint of "alarm compounds," which warn animals of the same species that there is danger present. These alarm compounds could be used as "dispersants" during a chemical treatment, thereby exposing more bugs to the treatment.

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Comments
  1. Aziz Safar Aziz Safar Australia says:

    Great study i hope you can expand your exploration into these fascinating insects.. perhaps their relationship with humans is a mutualistic one instead of parasitic in controlled environments.. e.g. cupping is used to draw bad blood out of the body allowing the body to function better and bone marrow to be healthier.. maybe bed bugs can be used in the same way.

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