MVP receives European patent for PEG conjugates of interferon-beta-1b to treat MS

Published on June 12, 2012 at 12:00 AM · No Comments

Mountain View Pharmaceuticals, Inc. ("MVP") announced its receipt of European Patent No. 1 667 708 B1, titled "Polyethylene Glycol Conjugates of Interferon-beta-1b with Enhanced in vitro Biological Potency." The conjugates covered by this patent could enable less frequent and better tolerated dosing of one of the most widely used treatments worldwide for relapsing-remitting multiple sclerosis, interferon-beta-1b.    

MVP also announced the publication of an invited scientific report, titled "Next-Generation PEGylation Enables Reduced Immunoreactivity of PEG-Protein Conjugates," in the June 2012 issue of Drug Development & Delivery.

"In contrast with other patents and publications relating to PEG conjugates of interferon-beta, MVP's new European patent claims polymer conjugates of interferon-beta-1b that have increased in vitro potency, measured with human cancer cells in culture, and methods of synthesis of these novel conjugates," stated Dr. Mark G. P. Saifer, MVP's Vice President and Scientific Director. "If our preclinical results are predictive of the performance of the PEG conjugates in humans, conversion of interferon-beta-1b to a long-acting form with higher potency could enhance the utility of this drug in the treatment of multiple sclerosis, viral infections and other conditions."

Patents disclosing and claiming PEG conjugates of interferon-beta-1b have been granted to MVP previously in 13 countries outside of Europe. The new European patent, with 46 claims including claims to methoxyPEG ("mPEG") and hydroxyPEG conjugates of non-glycosylated interferon-beta, will be a key component of the company's partnering and licensing activities.

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